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However, because the brain uses the same dopamine pathways for other rewards (like shopping, alcohol, or even social interaction), some researchers believe the drug may act as a general reward dampener

Jett, L., et al

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A decline in ACE2 function in aged individuals, coupled with the age-associated deterioration in mitochondrial functions results in chronic metabolic disorders like diabetes or cancer, and predisposes the host for increased susceptibility to infection, vulnerability to health complications, and intensifies the risk of mortality 163